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Chlamydia trachomatis Antibody (IgM)
Test CodeChlamydia trachomatis Antibody (IgM)
Quest Code
5157
CPT Codes
86632
Preferred Specimen
1 mL serum
Minimum Volume
0.1 mL
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 7 days
Refrigerated: 14 days
Frozen: 30 days
Refrigerated: 14 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Grossly lipemic • Grossly icteric
Methodology
Immunofluorescence Assay (IFA)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Mon-Sat; Report available: Next day
Reference Range
<1:10
Clinical Significance
Chlamydia trachomatis is associated with infections of the mucous membranes of the urogenital system, the upper respiratory tract, and the eye.
The usefulness of serological tests depends on the site of infection, duration of disease, infecting serovars and previous exposure to chlamydial antigens. Because C. trachomatis is ubiquitous, there is a high prevalence of antibodies in sexually active populations. Individuals may be reinfected and IgM antibodies may not appear. IgG antibodies may persist even after treatment, making assessment of a single IgG titer difficult. Consequently, serological diagnosis is seldom used to diagnose genital tract infections. Instead, Nucleic Acid Amplification Testing (NAAT) or culture should be considered to detect chlamydia trachomatis. Culture can also be used to diagnose infant respiratory infection or conjunctivitis.
The usefulness of serological tests depends on the site of infection, duration of disease, infecting serovars and previous exposure to chlamydial antigens. Because C. trachomatis is ubiquitous, there is a high prevalence of antibodies in sexually active populations. Individuals may be reinfected and IgM antibodies may not appear. IgG antibodies may persist even after treatment, making assessment of a single IgG titer difficult. Consequently, serological diagnosis is seldom used to diagnose genital tract infections. Instead, Nucleic Acid Amplification Testing (NAAT) or culture should be considered to detect chlamydia trachomatis. Culture can also be used to diagnose infant respiratory infection or conjunctivitis.
Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153
Last Updated: August 20, 2019
