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Gliadin (Deamidated) Antibody (IgA)
Test CodeGliadin (Deamidated) Antibody (IgA)
Quest Code
11228
Alias/See Also
Deamidated Peptide (Gliadin) IgA
Anti-Gliadin Deamidated Peptide
Gluten IgG (Gliadin)
Gliadin (Deamidated Peptide)
Anti-Gliadin Deamidated Peptide
Gluten IgG (Gliadin)
Gliadin (Deamidated Peptide)
CPT Codes
86258
Preferred Specimen
1 mL serum
Minimum Volume
0.3 mL
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 7 days
Refrigerated: 14 days
Frozen: 30 days
Refrigerated: 14 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Grossly lipemic
Methodology
Immunoassay (IA)
Setup Schedule
Set up: Tues-Sat; Report available: Next day
Reference Range
<15.0 U/mL | Antibody not detected | ||
≥15.0 U/mL | Antibody detected |
Clinical Significance
Detection of antibodies to gliadin, one of the major protein components of gluten, is a sensitive assay useful in diagnosing celiac disease. However, gliadin antibodies may be found in individuals without celiac disease; thus gliadin antibody assays are less specific than assays measuring antibodies to endomysium and transglutaminase. Recent work has revealed that gliadin-reactive antibodies from celiac patients bind to a very limited number of specific epitopes on the gliadin molecule. Further, deamidation of gliadin results in enhanced binding of gliadin antibodies. Based on this information, assays using deamidated gliadin peptides bearing the celiac-specific epitopes have much higher diagnostic accuracy for celiac disease when compared to standard gliadin antibody assays.
Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Dr
Chantilly, VA 20153
Last Updated: September 4, 2019