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Cyclic Citrullinated Peptide (CCP) Antibody (IgG)
Test CodeCCP
Quest Code
11173
Alias/See Also
Anti-CCP IgG
CCP
Cyclic Citrullinated Peptide, Ab, IgG
CCP
Cyclic Citrullinated Peptide, Ab, IgG
CPT Codes
86200
Preferred Specimen
1 mL serum
Minimum Volume
0.5 mL
Transport Container
Plastic screw-cap vial
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 4 days
Refrigerated: 7 days
Frozen: 30 days
Refrigerated: 7 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Gross lipemia • Plasma
Methodology
Immunoassay (IA)
Setup Schedule
Set up: Tues-Sat a.m.; Report available: Next day
Limitations
The presence of immune complexes may cause false-positive results due to increased non-specific binding.
Reference Range
Negative | <20 Units | ||||
Weak positive | 20-39 Units | ||||
Moderate positive | 40-59 Units | ||||
Strong positive | >59 Units |
Clinical Significance
A synthetic circular peptide containing citrulline called CCP IgG (cyclic citrullinated peptide) has been found to be better at discriminating Rheumatoid Arthritis patients from patients with other diseases such as hepatitis C infection. Rheumatoid Arthritis Classification Criteria include CCP IgG Antibody, rheumatoid factor, C-reactive protein and erythrocyte sedimentation rate (ESR). Approximately 70% of patients with Rheumatoid Arthritis are positive for Anti-CCP IgG, while only about 2% of random blood donors and disease controls subjects are positive.
Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153
Last Updated: September 3, 2019