A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Soluble Liver Antigen (SLA) Autoantibody
Test CodeSLAAA
Quest Code
38928
CPT Codes
83520
Preferred Specimen
1 mL serum
Minimum Volume
0.3 mL
Instructions
Centrifuge serum specimens, transfer serum to a sterile, plastic, screw-capped vial(s).
Refrigerate at 2-8°C, and send on refrigerant coolants to the laboratory. If shipping is delayed, freeze at -20°C, or lower (avoid freeze/thaw cycles) and send frozen samples on dry ice.
Refrigerate at 2-8°C, and send on refrigerant coolants to the laboratory. If shipping is delayed, freeze at -20°C, or lower (avoid freeze/thaw cycles) and send frozen samples on dry ice.
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 48 hours
Refrigerated: 8 days
Frozen: 28 days
Refrigerated: 8 days
Frozen: 28 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Lipemia
Methodology
Immunoassay (IA)
Setup Schedule
Set up: Tues, Thurs; Report available: Next day
Reference Range
<20.1 U | Negative |
20.1-24.9 U | Equivocal |
≥25.0 U | Positive |
Clinical Significance
Anti-soluble liver antigen antibodies are detected in 10-30% of patients with type 1 autoimmune hepatitis (AIH), but not in patients with type 2 AIH, primary sclerosing cholangitis or primary biliary cirrhosis. The antibody is directed against a UGA suppressor tRNA-associated protein. In some patients with AIH, this antibody may be the only autoantibody detected by current assays.
Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153
Last Updated: July 9, 2018