| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Islet Cell Antibody Screen with Reflex to Titer
Test CodeISLETAB
Quest Code
36741
Alias/See Also
ISLETAB
ICA
Islet Cell Ab
Pancreatic Islet Cell Ab
Type I Diabetes Ab
ICA
Islet Cell Ab
Pancreatic Islet Cell Ab
Type I Diabetes Ab
CPT Codes
86341
Includes
If Islet Cell Antibody Screen is positive, then Islet Cell Antibody Titer will be performed at an additional charge (CPT code(s): 86341).
Preferred Specimen
2 mL serum
Patient Preparation
Fasting specimen is preferred
Minimum Volume
0.5 mL
Transport Container
Plastic screw-cap vial
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 48 hours
Refrigerated: 14 days
Frozen: 6 months
Refrigerated: 14 days
Frozen: 6 months
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Grossly lipemic • Grossly icteric
Methodology
Immunofluorescence Assay (IFA)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Mon-Thurs; Report available: 5-9 days
Reference Range
| Islet Cell Antibody Screen | Negative |
| Islet Cell Antibody Titer | <1.25 JDF units |
Clinical Significance
Type 1 diabetes is characterized by lymphocytic cell infiltrate of the pancreatic islets. Measurement of GAD-65, ICA-512, and Insulin Antibody is a highly sensitive means to assess risk and predict onset of Type 1 diabetes. There is a correlation between the number of positive antibodies and the antibody titers versus the severity of the autoimmune process.
Performing Laboratory
| Quest Diagnostics Nichols Institute-San Juan Capistrano, CA |
| 33608 Ortega Highway |
| San Juan Capistrano, CA 92675-2042 |
Last Updated: October 7, 2019
