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Beta-2-Glycoprotein I Antibody (IgM)
Test CodeB2GPABM
Quest Code
36553
CPT Codes
86146
Preferred Specimen
3 mL platelet-poor plasma collected in a 3.2% sodium citrate (light blue-top) tube
Minimum Volume
2 mL
Other Acceptable Specimens
1 mL serum
Instructions
Plasma: Centrifuge light blue-top tube 15 minutes at approximately 1500 g within 60 minutes of collection. Using a plastic pipette, remove plasma, taking care to avoid the WBC/platelet buffy layer and place into a plastic vial. Centrifuge a second time and transfer platelet-poor plasma into a new plastic vial. Plasma must be free of platelets (<10,000/mcL).
Transport Container
Plastic screw-cap vial
Transport Temperature
Refrigerated/Frozen
Specimen Stability
Room temperature: 5 days
Refrigerated: 14 days
Frozen: 30 days
Refrigerated: 14 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Grossly lipemic
Methodology
Immunoassay (IA)
Setup Schedule
Set up: Mon-Sat; Report available: 3-4 days
Limitations
Factor VIII inhibitors may cause a false-positive lupus anticoagulation test. The temporary presence of antiphospholipid antibodies may accompany infections or certain drugs.
Reference Range
| Value | Interpretation |
| <20 U/mL | Antibody not detected |
| ≥20 U/mL | Antibody detected |
Clinical Significance
Beta-2-Glycoprotein 1, apolipoprotein H, is a cofactor in antiphospholipid antibody binding and is the critical antigen in the antiphospholipid antibody syndrome. Beta-2- Glycoprotein 1 antibody is more specific than cardiolipin antibody that may express reactivity in patients with syphilis and other infectious diseases.
Performing Laboratory
| Quest Diagnostics Nichols Institute |
| 14225 Newbrook Drive |
| Chantilly, VA 20153 |
Last Updated: August 14, 2019
