17-Hydroxy Progesterone, Urine

39488

10 mL aliquot of a 24 hour urine submitted in a plastic, leak-proof container

5 mL

10 mL random urine

Patient should not be on any Corticosteroid, ACTH, Estrogen, or Gonadotropin medications, if possible, for at least 48 hours prior to collection of specimen. No special preservatives are required.

Store specimens refrigerated during collection. Specimens should be frozen prior to shipping.
Note: Ship specimens frozen on dry ice. Provide the total volume.

Frozen

Room temperature: 1 hour
Refrigerated: 4 days
Frozen: 6 months

Set up: Test batched 1-5 times per week; Report available: 10 days

Pediatric

Newborns and Infants		3 Days-1 Year	up to 50	ng/24 hrs
Children		1-8 years	up to 300	ng/24 hrs

Adult

Male	up to 2.0	ug/24 hrs
Female	up to 4.5	ug/24 hrs

17-Hydroxy Progesterone is a steroid derived primarily from enzymatic metabolism of progesterone and 17-Hydroxy Pregnenolone. It is converted enzymatically to androstenedione and 11-Deoxycortisol. It is produced in both the gonads and adrenal glands. It is excreted into the urine in conjugated and unconjugated forms of 17-Hydroxy Progesterone and as pregnanetriol. This assay measures the total of the conjugated and unconjugated forms. It is stimulated by ACTH and suppressed by dexamethasone. Levels of urine 17-Hydroxy Progesterone are greatly increased in patients with polycystic ovarian disease and congenital adrenal hyperplasia and show exaggerated responses to ACTH in these cases. 17-Hydroxy Progesterone is the marker steroid for determining cases of 21 alpha-hydroxylase deficient congenital adrenal hyperplasia. Urine levels are frequently elevated in patients with idiopathic hirsutism.