Acetaminophen Level

Test Code

Alias/See Also

CPT Codes

Preferred Specimen
Serum - Red top NO GEL

Minimum Volume
1.0 mL

Other Acceptable Specimens
Plasma- EDTA (Lavender)
Serum- Red Top

Sample cannot be collected in tubes containing seperating gels.

Specimen Stability
Room Temperature: 24 hours at 25-30°C
Refrigerated: 7 days at 2-8°C
Frozen: 6 months at -20 °C. Freeze only once.

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolyzed, Lipemic and Icteric are unacceptable – ask for a new specimen to be drawn


Setup Schedule

Report Available
Same day

Reference Range
10-30 ug/mL

Critical Values:
>50 µg/mL
Canned comment for each Acetaminophen critical will read: 
Critical Value >  50 µg/mL   12 hours after ingestion
Critical Value > 150 µg/mL   4 hours after ingestion

Clinical Significance
Acetaminophen is a common drug used in many formulations due to its analgesic and antipyretic properties. Chronic excessive use of acetaminophen can result in hepatotoxicity and nephrotoxicity. Overdosage can lead to severe hepatic damage and hepatic failure if untreated. Early diagnosis of acetaminophen induced hepatotoxicity is important since initiation of therapy within 16 hours of ingestion lessens the potential for hepatic injury and decreases the mortality rate.

Performing Laboratory

Frederick Health Laboratory
400 W 7th Street
Frederick, MD  21701

Last Updated: October 22, 2021

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.