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TRANSFERRIN
Test CodeTRNS
Alias/See Also
TF
CPT Codes
84466
Preferred Specimen
1.0 mL collected in a LiHep tube
Minimum Volume
0.5 mL
Other Acceptable Specimens
Serum
Specimen Stability
Room Temperature: 8 days at 20-25°C
Refrigerated: 8 days at 2-8°C
Frozen: 6 months at -20 °C. Freeze only once.
Refrigerated: 8 days at 2-8°C
Frozen: 6 months at -20 °C. Freeze only once.
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Samples not labeled with complete first and last name, date of birth, date and time of collection.
Grossly hemolyzed.
Grossly hemolyzed.
Methodology
Immunoturbidmetric
Limitations
In very rare cases, gammopathy, in particular type IgM (Waldenström’s macroglobulinemia), may cause unreliable results.
Reference Range
203 – 362 mg/dL
Clinical Significance
Transferrin is a glycoprotein with a molecular weight of 79570 daltons. It consists of a polypeptide strand with two N-glycosidically linked oligosaccharide chains and exists in numerous isoforms. The rate of synthesis in the liver can be altered in accordance with the body’s iron requirements and iron reserves.
Transferrin is the iron transport protein in serum. In cases of iron deficiency, the degree of transferrin saturation appears to be an extremely sensitive indicator of functional iron depletion. The ferritin levels are depressed when there is a deficiency of storage iron. In sideropenia, an iron deficiency can be excluded if the serum transferrin concentration is low, as in inflammations or - less commonly - in cases of ascorbic acid deficiency. In screening for hereditary hemochromatosis, transferrin saturation provides a better indication of the homozygous genotype than does ferritin. The treatment of anemia with erythropoietin in patients with renal failure is only effective when sufficient depot iron is present. The best monitoring procedure is to determine transferrin saturation during therapy. Transferrin saturation in conjunction with ferritin gives a conclusive prediction of the exclusion of iron overloading in patients with chronic liver disease.F
Transferrin is the iron transport protein in serum. In cases of iron deficiency, the degree of transferrin saturation appears to be an extremely sensitive indicator of functional iron depletion. The ferritin levels are depressed when there is a deficiency of storage iron. In sideropenia, an iron deficiency can be excluded if the serum transferrin concentration is low, as in inflammations or - less commonly - in cases of ascorbic acid deficiency. In screening for hereditary hemochromatosis, transferrin saturation provides a better indication of the homozygous genotype than does ferritin. The treatment of anemia with erythropoietin in patients with renal failure is only effective when sufficient depot iron is present. The best monitoring procedure is to determine transferrin saturation during therapy. Transferrin saturation in conjunction with ferritin gives a conclusive prediction of the exclusion of iron overloading in patients with chronic liver disease.F
Performing Laboratory
Frederick Health Laboratory
400 W Main St
Frederick, MD 21701
Last Updated: March 22, 2022
