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Creatine Kinase
Test CodeCK
Alias/See Also
CPK
Creatine Phosphokinase
Creatine Phosphokinase
CPT Codes
82550
Preferred Specimen
1.0 mL plasma collected in a PST (LiHeparin tube)
Minimum Volume
0.5 mL
Other Acceptable Specimens
Plasma - EDTA (lavendar)
Serum - SST
Red top
or Tiger top
Serum - SST
Red top
or Tiger top
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 2 days at 15 - 25°C Refrigerated: Plasma 7 days at 2 - 8°C Frozen: 4 weeks at -15°C to -25°C
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Samples must be labeled with patient's complete first and last name and date of birth.
The collection time needs to be indicated on the tube or requisition.
Grossly hemolyzed, lipemic, and icteric are unacceptable.
The collection time needs to be indicated on the tube or requisition.
Grossly hemolyzed, lipemic, and icteric are unacceptable.
Methodology
Enzymatic
Setup Schedule
Sun - Sat
Report Available
Same Day
Reference Range
30 - 223 U/L
Clinical Significance
The CK enzyme is a dimer composed of subunits derived from either muscle (M) or brain (B). Three isoenzymes have been identified: MM, MB, and BB. Normal serum CK is predominantly the CK-MM isoenzyme. Elevated CK-serum levels are found in skeletal muscle disease, particularly muscular dystrophy. The CK-MB fraction is found primarily in myocardial tissue and its presence is generally detected within the 48-hour period following the onset of a myocardial infarction. The use of total CK and CK-MB in the diagnosis of myocardial infarction is the most important single application of CK measurement in clinical chemistry. Serum CK activity is also increased after cerebral ischemia, acute cerebrovascular disease, and head injury.
Performing Laboratory
Frederick Health Laboratory
400 W 7th Street
Frederick, MD 21701
Last Updated: December 28, 2023