Alkaline Phosphatase

Test Code

ALP

Alias/See Also

ALK PHOS

CPT Codes
84075

Preferred Specimen

1.0 mL plasma collected in a PST (LiHeparin tube)

Minimum Volume

0.5 mL

Other Acceptable Specimens

Serum- SST, Red Top or Tiger Top

Specimen Stability

Room Temperature: 7 days at 20-25°C
Refrigerated: 7 days at 4-8°C
Frozen: 2 months at -20 °C. Freeze only once.

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Grossly Hemolyzed, Lipemic and Icteric are unacceptable

Methodology
Colorimetric

Setup Schedule

Mon-Sun

Report Available

Same day

Reference Range

38 – 136 U/L

Clinical Significance

Alkaline phosphatase in serum consists of four structural genotypes: the liver-bone-kidney type, the intestinal type, the placental type and the variant from the germ cells. It occurs in osteoblasts, hepatocytes, leukocytes, the kidneys, spleen, placenta, prostate and the small intestine. The
liver-bone-kidney type is particularly important.

A rise in the alkaline phosphatase occurs with all forms of cholestasis, particularly with obstructive jaundice. It is also elevated in diseases of the skeletal system, such as Paget’s disease, hyperparathyroidism, rickets and osteomalacia, as well as with fractures and malignant tumors. A considerable rise in the alkaline phosphatase activity is sometimes seen in children and juveniles. It is caused by increased osteoblast activity following accelerated bone growth.

Performing Laboratory
Frederick Health Laboratory
400 W 7th Street
Frederick, MD 21701

Last Updated: October 24, 2024

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.