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URIC ACID
MessageFor Uric Acid testing on urine see Uric Acid 24 hr urine or Uric Acid random Urine.
Test Code
URIC
Alias/See Also
Urate
CPT Codes
84550
Preferred Specimen
1.0 mL plasma collected in a PST (LiHeparin tube)
Patient Preparation
See instructions below foratients being treated with Rasburicase (recombinant urate oxidase)
Minimum Volume
0.5 mL
Other Acceptable Specimens
Serum- SST, Red Top or Tiger Top
Sterile Cup, B-D urine foley and BD specimen cup collection kit
Sterile Cup, B-D urine foley and BD specimen cup collection kit
Instructions
Patients treated with Rasbuuricase (recombinant urate oxidase)
Collect sample in pre-chilled green top (PST) tube. Place tube immediately into container of we ice. Centrifuge sample in pre-cooled centrifuge. Analyze sample within 4 hours of collection.
Collect sample in pre-chilled green top (PST) tube. Place tube immediately into container of we ice. Centrifuge sample in pre-cooled centrifuge. Analyze sample within 4 hours of collection.
Specimen Stability
Room Temperature: Plasma \Serum Not Specified
Urine 4 days at 15-25°C
Refrigerated: Plasma \Serum 5 days at 2-8°C
Urine (acidified) Not Specified
Frozen: Plasma/Serum 6 months at -20°C Urine Not Specified
Urine 4 days at 15-25°C
Refrigerated: Plasma \Serum 5 days at 2-8°C
Urine (acidified) Not Specified
Frozen: Plasma/Serum 6 months at -20°C Urine Not Specified
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Samples not labeled with complete first and last name of patient and date of birth.
Grossly hemolyzed, lipemic and icteric specimens.
Grossly hemolyzed, lipemic and icteric specimens.
Methodology
Enzymatic colorimetric
Setup Schedule
Daily
Report Available
Same day
Limitations
• Drugs: No interference was found at therapeutic concentrations using common drug panels.
Exceptions: Calcium dobesilate causes artificially low uric acid results.
• Uricase reacts specifically with uric acid. Other purine derivatives can inhibit the uric acid reaction.
• Dicynone (Etamsylate) at therapeutic concentrations may lead to false-low results.21
• Acetaminophen intoxications are frequently treated with N-Acetylcysteine. N-Acetylcysteine at the therapeutic concentration when used as an antidote and the Acetaminophen metabolite N-acetyl-p-benzoquinone imine (NAPQI) independently may cause falsely low results.
• Venipuncture should be performed prior to the administration of Metamizole. Venipuncture immediately after or during the administration of Metamizole may lead to falsely low results.
• In very rare cases, gammopathy, in particular type IgM (Waldenström’s macroglobulinemia), may cause unreliable results.
Exceptions: Calcium dobesilate causes artificially low uric acid results.
• Uricase reacts specifically with uric acid. Other purine derivatives can inhibit the uric acid reaction.
• Dicynone (Etamsylate) at therapeutic concentrations may lead to false-low results.21
• Acetaminophen intoxications are frequently treated with N-Acetylcysteine. N-Acetylcysteine at the therapeutic concentration when used as an antidote and the Acetaminophen metabolite N-acetyl-p-benzoquinone imine (NAPQI) independently may cause falsely low results.
• Venipuncture should be performed prior to the administration of Metamizole. Venipuncture immediately after or during the administration of Metamizole may lead to falsely low results.
• In very rare cases, gammopathy, in particular type IgM (Waldenström’s macroglobulinemia), may cause unreliable results.
Reference Range
Plasma /Serum
Adult Female: 2.3 – 6.6 mg/dL
Adult Male: 4.4 – 7.6 mg/dL
Urine
250 - 800 mg/24hrs (24hr urine)
Adult Female: 2.3 – 6.6 mg/dL
Adult Male: 4.4 – 7.6 mg/dL
Urine
250 - 800 mg/24hrs (24hr urine)
Clinical Significance
Uric acid is the final product of purine metabolism in the human organism. Uric acid measurements are used in the diagnosis and treatment of numerous renal and metabolic disorders, including renal failure, gout, leukemia, psoriasis, starvation or other wasting conditions, and of patients receiving cytotoxic drugs.
Performing Laboratory
Frederick Health Laboratory
400 W 7th Street
Frederick, MD 20701
Last Updated: August 7, 2023
