CKMB Panel

Test Code

CKMBP

Alias/See Also

CPK-MB
CPKMB

CPT Codes
82553, 82550

Includes

CK MB
Total CK
%CKMB

Preferred Specimen

1.0 mL plasma collected in a PST (LiHeparin tube)

Minimum Volume

0.5 mL

Other Acceptable Specimens

Plasma - Li Heparin (PST)
Plasma - Na Heparin
Plasma - EDTA (Lavender)
Gold top (SST)
Tiger top (SST)
Red top

Transport Temperature

Refrigerated

Specimen Stability

Room temperature: 5 hours at 20 - 25°C
Refrigerated: 12 hours at 2 - 8°C
Frozen: 3 month at 20°C. Freeze only once.

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Samples not labeled with complete first and last name of patient and date of birth.
Grossly hemolyzed, lipemic, and icteric are unacceptable.

Methodology
CK = Enzymatic CKMB = Electrochemiluminescence immunoassay

Setup Schedule

Sun - Sat

Report Available

Same day

Reference Range

CK            30 - 223 U/L

CKMB Females < 3.8 ng/mL
         Males     < 6.7 ng/mL

% CKMB  0 - 4%

Clinical Significance

Creatine kinase (CK) is a dimeric enzyme which occurs in four different forms: a mitochondrial isoenzyme and the cytosolic isoenzymes CK-MM (muscle type), CK-BB (brain type) and CK-MB. The determination of CK-MB mass in serum is an important element in the diagnosis of myocardial ischemia, e.g., in acute myocardial infarction, myocarditis, etc. CK-MB is detectable in the blood about 3 to 8 hours after the onset of cardiac symptoms and can remain detectable over a lengthy period of time, depending on the course of the condition. CK-MB may also appear in other clinical conditions, e.g., in rhabdomyolysis and stroke. Within the scope of laboratory diagnostics, the determination of total CK, troponin T and/or myoglobin can contribute to the differentiation of these clinical pictures. The sensitivity of a CK-MB determination is dependent upon the time at which a sample was taken. Follow-up assays are therefore meaningful.

Performing Laboratory
Frederick Health Laboratory
400 W 7th Street
Frederick, MD 21701

Last Updated: May 5, 2020

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.