Chromosome Analysis and Alpha-Fetoprotein with Reflex to AchE and Fetal Hgb, Amniotic Fluid [14591Z]

Test Code

CHROMAF

Quest Code

14591

CPT Codes
82106, 88235, 88269, 88280<br>This test is for non-New York patient testing. For New York patient testing use test code 17581X

Physician Attestation of Informed Consent

This germline genetic test requires physician attestation that patient consent has been received if ordering medical facility is located in AK, DE, FL, GA, IA, MA, MN, NV, NJ, NY, OR, SD or VT or test is performed in MA.

Includes

If the amniotic fluid AFP MoM is ≥2.0, then Acetylcholinesterase and Fetal Hemoglobin by ID will be performed at an additional charge (CPT code(s): 82664, 83033).

Preferred Specimen

20 mL amniotic fluid collected in a sterile screw-cap container

Minimum Volume

5 mL

Instructions

30 mL is preferred if other testing, e.g., microarray, FISH, is ordered.

Ship at room temperature. Do not freeze.
Send all tubes to lab (supernatant for AFP will be split by cytogenetics lab).

Please contact the laboratory Genetic Counselor at 1-866-GENEINFO (1-866-436-3463) with any questions.

Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.

If sample exceeds stability, please call laboratory at ext. 4307 for instructions.

Transport Temperature

Room temperature

Specimen Stability

Room temperature: Preferred
Refrigerated: Acceptable
Frozen: Unacceptable

Methodology
Culture • Karyotype • Microscopy

AFP: Immunoassay (IA) • Gel Electrophoresis • Immunodiffusion (ID)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up: Daily; Report available: 9-12 days (additional days for reflex if needed)

Reference Range

See Laboratory Report

Clinical Significance

This test will detect chromosome abnormalities of the fetus including numerical, structural, and mosaic abnormalities. Chromosome analysis will also reveal fetal sex and sex chromosome abnormalities. Indications for prenatal chromosome analysis may include advanced maternal age, abnormal fetal ultrasound, abnormal maternal serum screen, abnormal cell-free DNA results, history of a previous child with a chromosome abnormality, or a parent who carries a balanced chromosomal rearrangement or has another chromosome abnormality.

Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153

Last Updated: October 1, 2017

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.