Dihydropyrimidine Dehydrogenase (DPYD)

Test Code

13603

Alias/See Also

5-FU
5-Fluorouracil
Capecitabine
DPD

CPT Codes
81232

Preferred Specimen

3 mL whole blood collected in an EDTA (lavender-top) tube, K2 EDTA (pink-top) tube, or ACD (yellow-top) tube

Minimum Volume

1 mL

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 72 hours
Refrigerated (cold packs): 7 days
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Plasma or serum • Heparinized specimens • Frozen specimens in glass collection tubes

Methodology
Polymerase Chain Reaction/Fluorescence Monitoring

FDA Status
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Setup Schedule

Set up: Varies; Report available: 5-10 days

Reference Range

See Laboratory Report

Clinical Significance

Predicts risk of dose-related toxicity to 5-FU therapy.

Performing Laboratory

A.R.U.P., Inc.

500 Chipeta Way

Salt Lake City, UT 84108-1221

Last Updated: February 26, 2026

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.