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CANDIDA IMMUNE COMPLEX
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Test Code
95856
CPT Codes
86332
Preferred Specimen
SERUM
Minimum Volume
2mL
Instructions
Allow blood to clot for 30 minutes. Centrifuge at 3000 rpm for 10 minutes. Separate serum and freeze immediately. Ship frozen on dry ice.
Transport Temperature
FROZEN
Specimen Stability
- Room temperature: Unacceptable
- Refrigerated: 7 days
- Frozen: 10 weeks
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis • Received room temperature
Methodology
Enzyme Linked Immunosorbent Assay (ELISA)
Reference Range
<0.90 Index
Clinical Significance
Candida Immune Complex - Candida Immune Complexes which form in vivo are comprised of Candida Albicans antigen, anti-Candida IgG antibodies, and complement. The presence of these complexes is an indication of overgrowth of C. albicans in the gut. Candida overgrowth was first described by Brabander and associates in 1957. Diagnosis of the condition has been difficult due to the ubiquitous nature of Candida resulting in the existence of antibodies to it in a large percentage of the normal population. It is also difficult to isolate by culture from stool due to the overgrowth by normal intestinal flora. Symptoms of Candida intestinal overgrowth include bloating, itching, and skin rashes. Lehman and Reiss suggested that the presence of immune complexes to Candida is an objective means of diagnosing the condition. The results of Broughton and Lanson concluded that the marker for Candida immune complexes not only aid in diagnosing intestinal overgrowth, but that levels of complexes decrease during successful treatment.
Last Updated: August 6, 2025
