Drug Monitoring, Novel Psychoactive Substances (NPS), Qualitative, Urine

Test Code

13086

CPT Codes
80364, 80347, 80352, 80371, 80376, 80354 (HCPCS: G0480)

Includes

Designer Benzodiazepines
Designer Fentanyl Analogs
Designer Opioids
Designer Stimulants
Synthetic Cannabinoids
Other Illicit Additives

NPS Comments will be automatically added

Preferred Specimen

3 mL urine collected in a plastic urine container

Minimum Volume

2 mL

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 7 days
Refrigerated: 14 days
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Preserved samples

Methodology
Mass Spectrometry (MS)

Setup Schedule

Set up: Mon-Sat; Report available: 1-3 days

Limitations

LIST OF SPECIFIC DESIGNER NAMES;

Drug Class        Drug Name
Designer          Aminoclonazolam       Etizolam
Benzodiazepines   Bromazolam            Flualprazolam
                  Clonazolam            Flubromazepam
                  Desalkylflurazepam    Flubromazolam
                  Deschloroetizolam     Fluetizolam
                  Hydroxy-Bromazolam    Phenazepam
                  Hydroxy-Flualprazolam
                  Hydroxy-Flubromazolam
                  4Cl-Deschloroalprazolam

Designer          Acetyl Fentanyl       Alfentanil
Fentanyl          Acryl Fentanyl        Carfentanil
Analogs           Butyryl/Isobutyryl Fentanyl
                  Chlorofentanyl        Sufentanil
                  Cyclopropyl Fentanyl
                  Fluorofentanyl
                  Furanyl Fentanyl
                  Methoxyacetyl Fentanyl
                  p-Fluorobutyryl Fentanyl
                  Tetrahydrofuranylfentanyl
                  Valeryl Fentanyl

Designer          2-Methyl AP-237       Isotonitazene
Opioids          Brorphine             Metonitazene
                  Hydroxy-Nitazene      Dipyanone
                  Etodesnitazene        Protonitazene

                  5Amino-Isotonitazene
                  5Methyl-Etodesnitazene
                  Desethyl Isotonitazene
                  Piperidinyl Etonitazene
                  Piperidinyl Hydroxynitazene
                  Pyrrolidino Etonitazene
                  Pyrrolidino Hydroxynitazene
                  Pyrrolidino Metonitazene
                  Pyrrolidino Protonitazene

Designer          2F-Deschloroketamine alpha-PVP
Stimulants        alpha-PHP/alpha-PiHP Eutylone
                  Cyclohexyl Butylone   Hydroxy-PCP
                  Cyclohexyl Methylone Pentylone
                  Dimethylpentylone
                  Fluorexetamine
                  Methylmethcathinone
                  Propyl Butylone

Synthetic         4F-MDMB-BUTICA        ADB-5Br-PINACA
Cannabinoids      4F-MDMB-BUTINACA      ADB-BINACA
                  5F-MDMB-PICA          ADB-BUTINACA
                  5F-MDMB-PICA M7       ADB-FUBIATA
                  ADB-5Br-BINACA        BZO-CHMOXIZID
                  BZO-4en-POXIZID       CH-FUBIATA
                  MDMB-4en-PINACA       CH-PIATA
                  4F-MDMB-BUTICA BA Metabolite
                  4F-MDMB-BUTINACA CI Metabolite
                  ADB-BUTINACA NBA Metabolite
                  ADB-BUTINACA NHB Metabolite
                  ADB-FUBIATA DBA Metabolite
                  MDMB-4en-PINACA BA Metabolite

Other Illicit     Xylazine              Tianeptine
Additives         Hydroxy-Xylazine

Reference Range

Designer Benzodiazepines	<10 ng/mL
Designer Fentanyl Analogs	<10 ng/mL
Designer Opioids	<10 ng/mL
Designer Stimulants	<10 ng/mL
Synthetic Cannabinoids	<10 ng/mL
Other Illicit Additives	<20 ng/mL

Clinical Significance

Novel psychoactive substances (NPS) are compounds designed to mimic the effects of prescription drugs, evade detection by typical drug testing methodologies, and avoid regulation. NPS can also be referred to as legal highs, Spice, Benzo Dope, Tranq Dope, or in products labelled "not for human use". NPS markets rapidly change in response to regulation from national and international agencies. These drugs are not typically detected by presumptive, immunoassay point-of-care or desktop analyzer drug tests. NPS may potentiate drug interactions with prescription medications, leading to unintended overdoses. Individuals may be exposed to illicit fentanyl or analogs, designer opioids, stimulants, and benzodiazepines, or xylazine, knowingly, or unknowingly through counterfeit prescription drugs intended to mimic common drugs such as oxycodone, hydrocodone, and alprazolam, among others. Updates and enhancements to our tested drug list are made from time to time based on surveillance data from the Center for Forensic Science Research and Education (CFSRE) and clinical patient trends. A complete and up to date list of the analytes contained in each drug class can be found at the bottom of each report and in our online FAQ.

Performing Laboratory

Quest Diagnostics Nichols Institute

14225 Newbrook Drive

Chantilly, VA 20153

Last Updated: August 14, 2024

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.