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Dihydropyrimidine Deydrogenase, DPYD Full Gene Sequencing
MessageOrder as a MISC test
Send whole blood specimen in original tube. Do not aliquot.
Test Code
DPYDZ
Alias/See Also
Capecitabine
5-Fluorouracil
DPD
5-Fluorouracil
DPD
CPT Codes
81232
Preferred Specimen
EDTA Whole Blood
Minimum Volume
3mL
Instructions
1. Invert several times to mix blood.
2. Send whole blood specimen in original tube. Do not aliquot.
2. Send whole blood specimen in original tube. Do not aliquot.
Transport Temperature
Ambient (preferred) 9 days/Refrigerated 30 days
Specimen Stability
Specimen preferred to arrive within 96 hours of collection.
Methodology
Polymerase Chain Reaction (PCR) followed by DNA Sequence Analysis
Setup Schedule
Monday through Friday
Report Available
5 to 10 days
Clinical Significance
Identifying individuals at increased risk of toxicity when considering 5-fluorouracil and capecitabine chemotherapy treatment
Identifying common and rare variants associated with decreased or absent dihydropyrimidine dehydrogenase (DPD) enzyme activity in individuals with suspected DPD deficiency
Identifying common and rare variants associated with decreased or absent dihydropyrimidine dehydrogenase (DPD) enzyme activity in individuals with suspected DPD deficiency
Performing Laboratory
MAYO
Last Updated: December 11, 2024
