Troponin T

TNTSINGLE

TNT

Li Heparin Plasma (PST)

0.10 mL

Refrigerated

Room Tempearture: none
Refrigerated: 2-8 C 25 hours
Frozen:  -20 C. 12 month

Sample not labeled with patient complete first, last name, and date of birth.
Date and time of collection must recorded on the sample or requisition
Grossly hemolysed sample.
 

24/7

Same day

Females	≤ 14 ng/L
Males	≤ 22 ng/L

 

Use caution in interpreting troponin values in patients who have presented within 3 hours of onset of chest pain due to the potential for false negative results. In our studies, troponin concentrations above the cutoff were sometimes only detected in these patients more than 7 hours after presentation to the emergency department. Serial sampling is required to determine a rise or fall in troponin over time. At certain timepoints, the PPV of this device is low. Troponin results should always be used in conjunction with clinical signs and symptoms.

Troponin T (TnT) is a component of the contractile apparatus of the striated musculature. Although the function of TnT is the same in all striated muscles, the cardiac isoform of TnT originating exclusively from the myocardium (cardiac TnT, molecular weight 39.7 kDa) clearly differs from skeletal muscle TnT.¹ As a result of its high tissue‑specificity, cardiac troponin T (cTnT) is a cardio‑specific, highly sensitive marker for myocardial damage. Cardiac troponin T increases rapidly (i.e. can be detected within 1 hour of observation time if using high‑sensitivity assays)² after acute myocardial infarction (AMI) and may persist up to 2 weeks thereafter.^3,4 In contrast to ST‑elevation myocardial infarction (STEMI), the diagnosis of non‑ST elevation myocardial infarction (NSTEMI) relies heavily upon elevated cardiac troponin (cTn) concentrations in the appropriate clinical context. The Fourth Universal Definition of Myocardial Infarction (MI) has confirmed cTn as the biomarker of choice.⁵ Diagnosis of MI is made with acute changes in cTn concentrations with at least one serial sample above the 99^th percentile upper reference limit (URL), taken together with evidence of myocardial ischemia (symptoms, electrocardiogram (ECG) changes or imaging results).