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15064 ENDOMYSIAL AB IGA
Test CodeENDOIGA
Includes
If Endomysial Antibody (IgA) Screen is positive, then Endomysial Antibody Titer will be performed at an additional charge (CPT code(s): 86231).
Preferred Specimen
1 mL serum
Minimum Volume
0.3 mL
Transport Container
Plastic screw-cap vial
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 7 days
Refrigerated: 21 days
Frozen: 21 days
Refrigerated: 21 days
Frozen: 21 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Grossly lipemic
Methodology
Immunofluorescence Assay (IFA)
Setup Schedule
Set up: Tues-Sat; Report available: Next day
Clinical Significance
The presence of anti-endomysial (EMA) IgA antibodies has been shown to correlate with gluten-sensitive enteropathy such as celiac disease (CD) and dermatitis herpetiformis (DH). EMA is detected primarily by IFA, using monkey esophagus as a substrate and observing fluorescence of the endomysial lining. Patients with CD and DH can also demonstrate antibodies to reticulin and gliadin, though EMA-IgA seems to be the most specific marker (specifically 94-100%).
