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IGA
Test CodeIMMIGA
Preferred Specimen
1 mL serum
Minimum Volume
0.5 mL
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 72 hours
Refrigerated: 7 days
Frozen: 90 days
Refrigerated: 7 days
Frozen: 90 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Grossly lipemic
Methodology
Immunoturbidimetric
Setup Schedule
Set up: Mon-Fri; Report available: 1-5 days
Limitations
IgA-deficient individuals may have circulating IgA antibodies that can mediate fatal anaphylactoid reactions if IgA is infused or transfused. The absence IgA antibodies does not necessarily indicate the patient may not suffer anaphalaxis because pre-existing antibodies to other serum proteins may exist and cause anaphalaxis.
Clinical Significance
Increased IgA is associated with monoclonal IgA myeloma, respiratory and gastrointestinal infections, and malabsorption; decreased IgA is found in selective IgA deficiency and in ataxia telangiectasia.