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15220 CYCLOSPORINE LEVEL
Test CodeCYCLOSP
Preferred Specimen
5 mL whole blood collected in an EDTA (lavender-top) tube
Patient Preparation
Optimum time to collect sample is 1 hour before next dose
Minimum Volume
2 mL
Other Acceptable Specimens
Whole blood collected in: Sodium heparin (green-top) tube
Instructions
Do not use gel barrier/serum separator tubes (SST) for collection.
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 7 days
Refrigerated: 6 days
Frozen: Unacceptable
Refrigerated: 6 days
Frozen: Unacceptable
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Clotted specimen
Methodology
Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Mon-Sat; Report available: Same day
Clinical Significance
Cyclosporine is a commonly used immunosuppressive drug in patients receiving transplants. LC/MS/MS methods have higher specificity for the parent compound than immunoassay. Therapeutic drug monitoring is useful to optimize dose and avoid toxicity. High cyclosporine levels can lead to nephrotoxicity; Low levels can lead to organ rejection following transplant. Peak concentrations are reached at around 3.5 hours after oral dosage. Elimination half-life is 10-27 hours.