NeoEncephalitis Paraneoplastic Evaluation with Recombx®

Test Code

91622

CPT Codes
86341, 83520 (x4), 83519, 86255 (x3)

Includes

Amphiphysin Antibody Test
CASPR2 Antibody Test
GAD65 Antibody Test
LGI1 Antibody Test
NMDA Receptor (NR1) Antibody Test, Recombx
MaTa Autoantibody Test, Recombx
CV2 Antibody Test, Recombx
Hu Autoantibody Test
VGKC Antibody Test

Preferred Specimen

2 mL serum

Minimum Volume

0.5 mL

Instructions

Serum must be separated from cells within 48 hours of collection.

Note: Please label each specimen tube with two forms of patient identification. These forms of identification must also appear on the requisition form.

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 72 hours
Refrigerated: 28 days
Frozen: 28 days

Methodology
Automated Nanoliter Scale Immunoassay • Enzyme Linked Immunosorbent Immunoassay (ELISA) • Radioimmunoassay (RIA) • Immunofluorescence Assay (IFA)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Athena Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up: Mon, Thurs; Report available: 7-10 days

Reference Range

See Laboratory Report

Clinical Significance

Anti-Hu, anti-CV2, anti-Ma, anti-Ta, anti-voltage gated potassium channels (VGKC), anti-Amphiphysin, anti-GAD65, anti-NMDA receptor (NR1-subunit), anti- LGI1, and anti-CASPR2 antibodies are found in patients with the acute or subacute onset of limbic encephalitis including confusion/dementia, depression/anxiety and/or seizures or hallucinations and usually MRI changes in medial temporal lobes. This semi-quantitative assay may be useful in monitoring therapeutic responses in select cases.

Performing Laboratory
Athena Diagnostics, Inc.
200 Forest Street, 2nd Floor
Marlborough, MA 01752

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.