A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Metanephrines, Fractionated, LC/MS/MS, 24-Hour Urine
Test Code14962
CPT Codes
83835
Includes
Metanephrine, Normetanephrine, Total Metanephrines
CPT code 81050 may be added at an additional charge for volume measurement
CPT code 81050 may be added at an additional charge for volume measurement
Preferred Specimen
5 mL of a 24-hour urine with 25 mL 6N HCl collected in a 24-hour urine container
Patient Preparation
It is preferable for the patient to be off medications for three days prior to collection. Patient should avoid tobacco, tea, coffee, for three days prior to specimen collection. Common antihypertensives (diuretics, ACE inhibitors, calcium channel blockers, alpha and beta blockers) cause minimal or no interference. Medications which are alpha agonists (Aldomet), alpha blockers (Dibenzyline) should be avoided 18-24 hours prior to specimen collection.
Minimum Volume
1.5 mL
Other Acceptable Specimens
Unpreserved 24-hour urine
Instructions
After urine collection, add 25 mL of 6N HCl to maintain a pH below 3. Urine without preservative is acceptable if pH is below 6 and the sample is shipped frozen. Record 24-hour urine volume on test request form and urine vial. Record patients age on test request form and urine vial.
Transport Temperature
Preserved urine: Room temperature
Unpreserved urine: Frozen
Unpreserved urine: Frozen
Specimen Stability
Preserved urine
Room temperature: 10 days
Refrigerated: 14 days
Frozen: 90 days
Unpreserved urine
Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Urine collected with boric acid
Methodology
Chromatography/Tandem Mass Spectrometry
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Mon-Sat; Report available: 2-4 days
Reference Range
Metanephrines, 24-Hour Urine | ||
Age | Reference Range | UOM |
3 months-4 years | 25-117 | mcg/24 h |
5-9 years | 11-139 | mcg/24 h |
10-13 years | 51-275 | mcg/24 h |
14-17 years | 40-189 | mcg/24 h |
18-29 years | 25-222 | mcg/24 h |
30-39 years | 36-190 | mcg/24 h |
40-49 years | 58-203 | mcg/24 h |
≥50 years | 90-315 | mcg/24 h |
Normetanephrines, 24-Hour Urine | ||
3 months-4 years | 54-249 | mcg/24 h |
5-9 years | 31-398 | mcg/24 h |
10-13 years | 67-503 | mcg/24 h |
14-17 years | 69-531 | mcg/24 h |
18-29 years | 40-412 | mcg/24 h |
30-39 years | 35-482 | mcg/24 h |
40-49 years | 88-649 | mcg/24 h |
≥50 years | 122-676 | mcg/24 h |
Metanephrines, Total 24-Hour Urine | ||
3 months-4 years | 79-345 | mcg/24 h |
5-9 years | 49-408 | mcg/24 h |
10-13 years | 110-714 | mcg/24 h |
14-17 years | 107-741 | mcg/24 h |
18-29 years | 94-604 | mcg/24 h |
30-39 years | 115-695 | mcg/24 h |
40-49 years | 182-739 | mcg/24 h |
≥50 years | 224-832 | mcg/24 h |
Clinical Significance
Test is useful in the evaluation of pheochromocytoma.
Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153