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Prostate-Specific Antigen (PSA), Total and Free, Serum or Plasma

Test Code
996


CPT Codes
84153-Total; 84154-Free

Preferred Specimen
Submit 1 of the following specimens:

Plasma
Container/Tube: Green top (lithium-heparin) tube(s)
Specimen Volume: 3 mL (minimum volume: 0.5 mL) of plasma

Serum
Container/Tube: Serum gel tube(s)
Specimen Volume: 3 mL (minimum volume: 0.5 mL) of serum

Note: 1. Avoid palpation of prostate for 14 days prior to test. 2. Rectal examination within 2 days of specimen collection may cause elevation of results.


Transport Temperature
Refrigerate 8 hours/Frozen OK 


Methodology
Electrochemiluminescent Immunoassay (ECLIA)

Setup Schedule
Monday through Friday


Reference Range
Total PSA
0.00-4.00 ng/mL
Free PSA Ratio
About 25% of asymptomatic men older than 50 years and PSA values of 4.0 to10 ng/ml have prostate cancer, compared with about 12% for those with PSA values of 2.0 to 3.9 ng/ml. Free PSA can help classify these men into subgroups. The probability of finding PCA with TPSA between 4.0 and 10.0 ng/ml increases with increasing age and with decreasing FPSA/TPSA ratios.


                                     Free/Total Ratio           Cancer Rate



TPSA: 4-10 ng/ml      <10%                               >49%                  



                                    >25%                              <15%



TPSA 2-3.9 ng/ml      <10%                               >30%



                                     >18%                             <10% 




Performed By
CoxHealth

Performing Laboratory
CoxHealth-FDC laboratory



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.