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Coombs, Direct, Blood
Test Code379
Alias/See Also
DAT
CPT Codes
86880
Preferred Specimen
EDTA whole blood and plain red-top whole blood are required.
Container/Tube: Pink-top (EDTA) tube and a plain, red-top tube-Serum gel tube is not acceptable.
Specimen Volume: Full tubes of blood
Collection Instructions: Label specimen with patient’s full name, hospital and Blood Bank identification numbers, date and time of draw and user
name of phlebotomist.
Instructions
Include patient’s medication and transfusion history
Transport Container
Refrigerate
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Serum gel tube is not acceptable
Methodology
Hemagglutination
Setup Schedule
Monday through Sunday
Reference Range
Negative (reported as positive or negative)
Clinical Significance
Useful for determining if the patient’s cells are coated with IgG or complement proteins. Positive direct Coombs usually occurs with warm autoimmune hemolytic anemias, transfusion reactions, hemolytic disease of the newborn, anti-drug antibodies, cold agglutinin disease, or chronic lymphocytic leukemia
Performed By
CoxHealth
