| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
CYP2C19
Test Code38467
CPT Codes
81225
Preferred Specimen
3 swabs from collection kit
Specimen Stability
Swabs: stable at room temperature for up to 20 hours after collection
Methodology
Real Time PCR
Setup Schedule
Monday through Sunday
Reference Range
| Metabolizer Phenotype | CYP2C19 Enzyme Activity | Genotypes |
|---|---|---|
| Normal Metabolizer (NM) | Normal | *1/*1 |
| Intermediate Metabolizer (IM) | Reduced | *1/*2, *1/*3, *2/*17, *3/*17 |
| Poor Metabolizer (PM) | Very Low or Absent | *2/*2, *2/*3, *3/*3 |
| Rapid Metabolizer (RM) | Increased | *1/*17 |
| Ultra-Rapid Metabolizer (UM) | Very Increased | *17/*17 |
Clinical Significance
Clopidogrel (Plavix) is widely used in the treatment of stroke, acute coronary syndrome, and other conditions characterized by a high risk of ischemic events. The most important enzyme involved in the activation of this pro-drug is CYP2C19. This test is a genetic test to determine which alleles a patient is carrying for the CYP2C19 enzyme. This information can then be interpreted to determine whether Clopidogrel would be an effective treatment, or if alternative therapies should be considered.
Interpretation of alleles and how this relates to a patient's ability to metabolize the drug will be included in an interpretive comment for the order.
Interpretation of alleles and how this relates to a patient's ability to metabolize the drug will be included in an interpretive comment for the order.
Performed By
CoxHealth
Performing Laboratory
CoxHealth
