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Acute/Chronic/Infectivity HBV profile
Test CodeMISC (Quest 5522)
Alias/See Also
Hepatitis B Virus Profile
Includes
- Hep. B Core Antibody (IGM) Quest 4848
- Hep. B Surface Antigen w/ reflex to confirm Quest 498
- Hep. Be Antibody Quest 556
- Hep. be Antigen Quest 555
Preferred Specimen
4 ml Serum - Minimum specimen = 2.0 ml
( Alternative specimen- Plasma from EDTA tube)
( Alternative specimen- Plasma from EDTA tube)
Transport Container
SST tube
Transport Temperature
Room Temperature
Specimen Stability
Room temp: 7 days, Refrigerated: 14 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis or gross lipemia.
Report Available
3 days
Clinical Significance
- Hep B Core-specific IgM class antibody has been detected in most acute infections and is a reliable marker for acute disease. In some cases, Hep B Core IgM antibody may be the only specific marker for the diagnosis of acute infection with Hepatitis B virus.
- Hep B Surface antigen usually appears in the serum after an incubation period of 1 to 6 months following exposure to Hepatitis B virus and peaks shortly after onset of symptoms. It typically disappears within 1 to 3 months. Persistence of Hepatitis B surface antigen for greater than 6 months is a prognostic indicator of chronic Hepatitis B infection.
- HBeAb appears in the early convalescence of HBV infection. With carrier state and chronic hepatitis, HbeAb may not develop.
- HBeAg indicates active HBV replication. Infectivity is evaluated based on HBeAg and HBsAg. When HBeAg persists much longer than 10 weeks, the patient is likely to develop chronic hepatitis and be a carrier.