Oxcarbazepine Metabolite

Test Code

TRILE (Quest 36637Z)

Includes

10-Hydroxycarbazepine

Preferred Specimen

1 mL serum collected in a red-top tube (no gel)

Minimum Volume

0.25 mL

Other Acceptable Specimens

Plasma collected in: EDTA (lavender-top) tube

Transport Container

Plastic screw-cap vial

Transport Temperature

Room Temperature: 3 Days, Refrigerated: 2 Weeks, Frozen: 2 Months

Specimen Stability

Room temperature: 72 hours
Refrigerated: 14 days
Frozen: 60 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Serum Separator Tube (SST^®)

Methodology
Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up: Mon-Sat p.m.; Report available: 1-3 days

Reference Range

10-Hydroxycarbazepine

8.0-35.0 mcg/mL

Clinical Significance

Oxcarbazepine (10, 11-dihydro-10-oxo-5H-dibenz (bf) azepine-5-carboxamide, Trileptal), a 10-keto analogue of carbamazepine, is an anticonvulsant for the treatment of both generalized tonic-clonic and partial seizures in children and adults. It can be administered alone or as adjunct to other anticonvulsants. Clinically significant effects of oxcarbazepine are observed when plasma levels of its active metabolite, 10-OH-carbazepine, are between 15 and 35 ug/mL. Toxic symptoms may occur when plasma levels exceed 35 ug/mL.

Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.