Copper, RBC [3481]

For Specimen Integrity during Extreme Weather see the “Lockbox Usage in Extreme Weather” document at the top of this page.

Test Code

Alias/See Also

CPT Codes
82525<br /> **This test is not available for New York patient testing.**

Preferred Specimen
0.5 mL red blood cells collected in an EDTA trace metal free (royal blue-top) tube

Minimum Volume
0.3 mL

Other Acceptable Specimens
Red blood cells collected in an EDTA (lavender-top), sodium heparin trace metal-free (royal blue-top), sodium heparin (green-top), sodium heparin lead-free (tan-top) or lithium heparin (green-top) tube.

Carefully clean skin prior to venipuncture.
Avoid hemolysis.
Avoid worksite collection.
Red blood cells Trace Metal. Centrifuge and separate RBC's into an acid washed plastic screw cap vial within two hours of collection.

Transport Temperature
Room temperature

Specimen Stability
Room temperature: 10 days
Refrigerated: 10 days
Frozen: Unacceptable

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Clotted • Gross hemolysis

Inductively Coupled Plasma/Mass Spectrometry (ICP/MS)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule
Set up: Sun, Wed, Fri a.m.; Report available: 2-5 days

Reference Range
0.53-0.91 mg/L

Clinical Significance
Copper is an essential element that is a cofactor of many enzymes. Copper metabolism is distributed in Wilson's disease, Menkes disease, primary biliary cirrhosis, and Indian childhood cirrhosis. Copper concentrations increase in acute phase reactions. Copper concentrations are decreased with nephrosis, malabsorption, and malnutrition. Copper concentrations are also useful to monitor patients, especially preterm newborns, on nutritional supplementation. Results of copper are often interpreted together with ceruloplasmin.

Performing Laboratory
Quest Diagnostics Nichols Institute Valencia
27027 Tourney Road
Valencia, CA 91355-5386

Last Updated: November 29, 2021

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.