Encephalopathy Autoimmune Evaluation Serum

Message
For Specimen Integrity during Extreme Weather see the Lockbox Usage in Extreme Weather” document at the top of this page.


Test Code
ENS2


CPT Codes
86255 x 21 86341 x 1 83519-ARBI (if appropriate) 84182-AGNBS (if appropriate) 86255-AINCS (if appropriate) 86256-AMPIS (if appropriate) 84182-AMIBS (if appropriate) 84182-AN1BS (if appropriate) 84182-AN2BS (if appropriate) 84182-CRMWS (if appropriate) 86255-DPPCS (if appropriate) 86256-DPPTS (if appropriate) 86256-GABIS (if appropriate) 86255-GFACS (if appropriate) 86256-GFATS (if appropriate) 86255-IG5CS (if appropriate) 86256-IG5TS (if appropriate) 86255-GL1CS (if appropriate) 86256-GL1TS (if appropriate) 86255-NFHCS (if appropriate) 86256-NIFTS (if appropriate) 86255-NFLCS (if appropriate) 86256-NMDIS (if appropriate) 84182-PC1BS (if appropriate) 84182-PCTBS (if appropriate)

Preferred Specimen
4 mL Serum from a Red Top tube


Patient Preparation
1. For optimal antibody detection, specimen collection is recommended prior to initiation of immunosuppressant medication or intravenous immunoglobulin treatment.

2. This test should not be requested in patients who have recently received radioisotopes, therapeutically or diagnostically, because of potential assay interference. The specific waiting period before specimen collection will depend on the isotope administered, the dose given, and the clearance rate in the individual patient. Specimens will be screened for radioactivity prior to analysis. Radioactive specimens received in the laboratory will be held 1 week and assayed if sufficiently decayed, or canceled if radioactivity remains.

3. Patient should have no general anesthetic or muscle-relaxant drugs in the previous 24 hours.

Minimum Volume
2.5 mL


Other Acceptable Specimens
Serum from an SST


Instructions
Allow blood to clot, centrifuge and transfer serum to a plastic vial.


Transport Container
Plastic vial


Transport Temperature
Refrigerated


Specimen Stability
Room Temperature: 72 Hours
Refrigerated: 28 Days
Frozen: 28 Days


Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis, gross lipemia, gross icterus


Methodology
Indirect Immunofluorescence Assay (IFA),
Cell-Binding Assay (CBA),
Western Blot (WB),
Immunoblot (IB),
Radioimmunoassay (RIA)

Setup Schedule
Monday - Sunday


Report Available
10 - 13 days


Clinical Significance
Evaluating new onset encephalopathy (noninfectious or metabolic) comprising confusional states, psychosis, delirium, memory loss, hallucinations, movement disorders, sensory or motor complaints, seizures, dyssomnias, ataxias, nausea, vomiting, inappropriate antidiuresis, coma, dysautonomias, or hypoventilation in serum specimens


Performing Laboratory
MAYO CLINIC LABORATORIES
200 FIRST ST
ROCHESTER, MN 55905


Last Updated: May 1, 2024


The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.