Hydrocodone and Metabolite, Serum

Message

For Specimen Integrity during Extreme Weather see the “Lockbox Usage in Extreme Weather” document at the top of this page.

Test Code

HYCDSR

CPT Codes
80361

Includes

Hydrocodone, Free and Hydromorphone, Free

Preferred Specimen

5 mL serum collected in a red-top (no gel)

Minimum Volume

2.5 mL

Transport Container

Plastic screw-cap vial

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 7 days
Refrigerated: 14 days
Frozen: 14 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Serum Separator Tubes (SST^®)

Methodology
Chromatography/Mass Spectrometry

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up: Tues, Sat a.m.; Report available: 2-5 days

Reference Range

Hydrocodone, Free	5.0-24.0 ng/mL
Hydromorphone, Free	5.0-30.0 ng/mL

Clinical Significance

Therapeutic drug monitoring and confirmation of screen- positive results. Hydrocodone is an active component of Vicodin®, Lorcet®, Lortab®, etc. Serum half-life is 3.4 to 8.8 hours. Hydromorphone is an active ingredient in Dilaudid®. Serum half-life is 1.5 to 3.8 hours.

Performing Laboratory
Quest Diagnostics Nichols Institute Valencia
27027 Tourney Road
Valencia, CA 91355-5386

Last Updated: November 30, 2021

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.