Gonadotropin Releasing Hormone

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Test Code

GRH

CPT Codes
83520<br><strong>This test is not available for New York patient testing.</strong>

Preferred Specimen

3 mL frozen plasma collected in an EDTA (lavender-top) tube

Patient Preparation
Patient should not be on any hormonal treatment for 2 days

Minimum Volume

0.7 mL

Instructions

Centrifuge and transfer 3 mL plasma into a transfer tube. Ship frozen.

Transport Container

Transport tube

Transport Temperature

Frozen

Specimen Stability

Room temperature: Unacceptable
Refrigerated: 6 hours
Frozen: 90 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Gross hemolysis • Serum

Methodology
Enzyme Linked Immunosorbent Assay (ELISA) • Extraction

FDA Status
This test was developed and its analytical performance characteristics have been determined by Pan Laboratories. This assay has been validated pursuant to the CLIA regulations. It has not been cleared or approved by the U.S. Food and Drug Administration.

Setup Schedule

Set up: Wed, Fri; Report available: 2-7 days

Reference Range

0-10.0 pg/mL

Clinical Significance

Gonadotropin releasing hormone (Gn RH or LH RH) is a ten amino acid peptide produced mainly in the hypothalamus. It stimulates pituitary for the production of LH and FSH. The stimulation is predominantly on LH secretion and hence it is called LH RH. LH and FSH stimulate the production of gonadal hormones (e.g testosterone in males and estrogens in females). These steroid hormones have a feedback control on Gn RH secretion. Increased secretion occurs during puberty leading to the raise in concentration of LH and FSH for the stimulation of gonads. LH RH levels are high when there is secondary hypogonadism with decreased level of LH and FSH. LH RH levels are low in tertiary (hypothalamic) hypogonadism and also individuals with high stress levels with elevated dopamine and prolactin. LH RH and its agonists are routinely used in IVF settings to induce ovulation.

Performing Laboratory
Pan Laboratories, LLC
15375 Barranca Pkw, E101
Irvine, CA 92618

Last Updated: November 29, 2021

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.