FISH, Follicular Lymphoma, IGH/BCL2, t(14;18)

Message

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Test Code

FOLLIC

CPT Codes
88275, 88271 (x2)

Includes

Note: If results are not possible, the test order may be canceled and replaced by a "Cytogenetics Communication".

Preferred Specimen

5 mL whole blood or 3 mL bone marrow collected in sodium heparin (green-top), sodium heparin (royal blue-top) or sodium heparin lead-free (tan-top) tube,or
5x5 mm fresh tissue collected in culture transport media or sterile container with Hanks' or Ringers solution, or
Tissue in Formalin-fixed paraffin-embedded tissue

Minimum Volume

1 mL whole blood or bone marrow • 5x5 mm tissue

Instructions

3-5 mL whole blood or 1-3 mL bone marrow collected in sodium heparin tube, 5x5 mm Fresh tissue in sterile container, Formalin Fixed Paraffin Embedded Tissue.

Specimen viability decreases during transit. Send specimen to testing laboratory for viability determination. Do not freeze. Do not reject.

Transport Temperature

Room temperature

Specimen Stability

Room temperature: See Instructions
Refrigerated: See Instructions
Frozen: See Instructions

Methodology
Fluorescence in situ Hybridization (FISH)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

A.M.

Reference Range

See Laboratory Report

Clinical Significance

Translocation t(14;18)(q32;q21.3) is assayed by FISH with probes from the regions IGH (14q32) and BCL2 (18q21.3) this assay is useful to diagnose follicular lymphoma (>75%) and diffuse large cell lymphomas (25%).

Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Dr
Chantilly, VA 20153

Last Updated: November 29, 2021

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.