Clostridium difficile Cytotoxin Antibody Neutralization

Message
For Specimen Integrity during Extreme Weather see the “Lockbox Usage in Extreme Weather” document at the top of this page.


Test Code
CDIFCY


CPT Codes
87230

Preferred Specimen
2 mL serum


Minimum Volume
1 mL


Transport Temperature
Refrigerated (cold packs)


Specimen Stability
Room temperature: Unacceptable
Refrigerated: 14 days
Frozen: 30 days


Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Stool • Other sterile body fluids • Received beyond stability • Received in inappropriate container


Methodology
Antibody Neutralization

Setup Schedule
Tuesday Morning Report available: 3 Days


Reference Range
<1:2 titer


Clinical Significance
Clostridium difficile is a major cause of antibiotic-associated diarrhea and pseudomembranous colitis. Clinical symptoms range from mild diarrhea to toxic megacolon. Antibodies may be present in a majority of adults and older children. Antibody production has been reported to be associated with carriers who appear asymptomatic and with reduced risk of recurrent disease. Natural exposure antibody may be a positive prognostic sign for patients with C. difficile disease.


Performing Laboratory
Quest Diagnostics Nichols Institute-San Juan Capistrano, CA
33608 Ortega Highway
San Juan Capistrano, CA 92675-2042



Last Updated: November 29, 2021


The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.