A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
FISH, B-cell Malignancy, IGH, 14q32 Rearrangement
MessageFor Specimen Integrity during Extreme Weather see the “Lockbox Usage in Extreme Weather” document at the top of this page.
Test Code
BCELL
CPT Codes
88275, 88271 (x2)
Includes
Note: If results are not possible, the test order may be canceled and replaced with a Cytogenetics Communication
Preferred Specimen
5 mL whole blood or 3 mL bone marrow collected in sodium heparin (green-top), sodium heparin (royal blue-top) or sodium heparin lead-free (tan-top) tube, or
5x5 mm fresh tissue collected in culture transport media or sterile container with Hanks' or Ringers solution, or
Tissue in Formalin-fixed paraffin-embedded tissue
5x5 mm fresh tissue collected in culture transport media or sterile container with Hanks' or Ringers solution, or
Tissue in Formalin-fixed paraffin-embedded tissue
Minimum Volume
1 mL whole blood or bone marrow • 5x5 tissue
Instructions
Clinical history and reason for referral are required with test order. Prior therapy and transplant history should be provided.
3-5 mL whole blood or 1-3 mL bone marrow collected in sodium heparin tube, 5x5 mm Fresh tissue in sterile container, Formalin Fixed Paraffin Embedded Tissue.
Specimen viability decreases during transit. Send specimen to testing laboratory for viability determination. Do not freeze. Do not reject.
3-5 mL whole blood or 1-3 mL bone marrow collected in sodium heparin tube, 5x5 mm Fresh tissue in sterile container, Formalin Fixed Paraffin Embedded Tissue.
Specimen viability decreases during transit. Send specimen to testing laboratory for viability determination. Do not freeze. Do not reject.
Transport Temperature
Room temperature
Specimen Stability
Room temperature: See Instructions
Refrigerated: See Instructions
Frozen: See Instructions
Refrigerated: See Instructions
Frozen: See Instructions
Methodology
Fluorescence in situ Hybridization (FISH)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Monday-Sunday Evening
Report available: 5 Days
Report available: 5 Days
Reference Range
See Laboratory Report
Clinical Significance
The splitting of IgH region of chromosome 14q32 is frequently implicated in translocations seen in a variety of hematological malignancies of B-cell origin.
Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Dr
Chantilly, VA 20153
Last Updated: November 29, 2021