Apolipoprotein Evaluation

For Specimen Integrity during Extreme Weather see the “Lockbox Usage in Extreme Weather” document at the top of this page.

APO

Apolipoprotein A1
Apolipoprotein B
Apolipoprotein B/A1 Ratio

1 mL serum collected in a serum separator tube (SST)

0.5 mL

Room temperature

Room temperature: 7 days
Refrigerated: 10 days
Frozen: 30 days

Grossly lipemic

Set up: Mon-Sat; Report available: 1-2 days

Apolipoprotein A1

Male	≥115 mg/dL
Female	≥125 mg/dL
Risk Category	Male	Female
Optimal	≥115 mg/dL	≥125 mg/dL
High	<115 mg/dL	<125 mg/dL

Cardiovascular event risk category cut points (optimal, high) are based on the AMORIS study, Walldius G et al. J Intern Med. 2004;255:188-205.

Apolipoprotein B	<90 mg/dL
Risk Category
Optimal	<90 mg/dL
Moderate	90-119 mg/dL
High	≥120 mg/dL

Cardiovascular event risk category cut points (optimal, moderate, high) are based on National Lipid Association recommendations-Jacobson TA et al. J of Clin Lipid. 2015; 9: 129-169 and Jellinger PS et al. Endocr Pract. 2017;23(Suppl 2):1-87.

Apolipoprotein B/A1 Ratio

Male	<0.77
Female	<0.63
Risk Category	Male	Female
Optimal	<0.77	<0.63
Moderate	0.77-0.95	0.63-0.78
High	>0.95	>0.78

Cardiovascular event risk category cut points (optimal, moderate, high) are based on the AMORIS study, Walldius G et al. J Intern Med. 2004;255:188-205.

Apolipoprotein A1 is the primary protein associated with HDL cholesterol. Like HDL cholesterol, increased concentrations are associated with reduced risk of cardiovascular disease. Apolipoprotein B-100 is the primary protein associated with LDL cholesterol and other lipid particles. Like LDL cholesterol, increased concentrations are associated with increased risk of cardiovascular disease. The ratio of these two apolipoproteins correlates with risk of cardiovascular disease.