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Soluble Liver Antigen (SLA) Autoantibody
Test CodeSLA
CPT Codes
83520
Preferred Specimen
1 mL serum
Minimum Volume
0.3 mL
Instructions
Centrifuge serum specimens, transfer serum to a sterile, plastic, screw-capped vial(s).
Refrigerate at 2-8°C, and send on refrigerant coolants to the laboratory. If shipping is delayed, freeze at -20°C, or lower (avoid freeze/thaw cycles) and send frozen samples on dry ice.
Refrigerate at 2-8°C, and send on refrigerant coolants to the laboratory. If shipping is delayed, freeze at -20°C, or lower (avoid freeze/thaw cycles) and send frozen samples on dry ice.
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 48 hours
Refrigerated: 8 days
Frozen: 28 days
Refrigerated: 8 days
Frozen: 28 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Lipemia
Methodology
Immunoassay (IA)
Setup Schedule
Set up: Tues, Thurs; Report available: Next day
Reference Range
| <20.1 U | Negative |
| 20.1-24.9 U | Equivocal |
| ≥25.0 U | Positive |
Clinical Significance
Anti-soluble liver antigen antibodies are detected in 10-30% of patients with type 1 autoimmune hepatitis (AIH), but not in patients with type 2 AIH, primary sclerosing cholangitis or primary biliary cirrhosis. The antibody is directed against a UGA suppressor tRNA-associated protein. In some patients with AIH, this antibody may be the only autoantibody detected by current assays.
Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153
