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Vedolizumab Quantitation w/Reflex to Antibodies
MessageFor Specimen Integrity during Extreme Weather see the “Lockbox Usage in Extreme Weather” document at the top of this page.
Test Code
VEDOL
Alias/See Also
Entyvio
CPT Codes
80280, 82397 if appropriate
Preferred Specimen
1.5 mL serum from a red top tube
Patient Preparation
1. For 12 hours before specimen collection do not take multivitamins or dietary supplements containing biotin (vitamin B7), which is commonly found in hair, skin, and nail supplements and multivitamins.
2. Nivolumab (Opdivo) must be discontinued at least 4 weeks prior to testing for vedolizumab quantitation in serum.
Minimum Volume
0.75 mL serum
Other Acceptable Specimens
Serum from an SST
Instructions
1. Draw blood immediately before next scheduled dose (trough specimen).
2. Centrifuge within 2 hours of draw.
3. Transfer serum to a pour off tube.
2. Centrifuge within 2 hours of draw.
3. Transfer serum to a pour off tube.
Transport Container
Pour off tube
Transport Temperature
Refrigerated
Specimen Stability
Room Temperature = N/a
Refrigerated = 28 days
Frozen = 28 days
Refrigerated = 28 days
Frozen = 28 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross Lipemia
Methodology
Liquid Chromatography- Mass Spectrometry (LC-MS/MS),
Electrochemiluminescent Bridging Immunoassay
Setup Schedule
Monday, Tuesday, Thursday, Friday
Report Available
7 - 14 days
Clinical Significance
Assessing the response to therapy with vedolizumab, An aid to achieving desired trough serum levels of vedolizumab, Monitoring patient compliance
Performing Laboratory
Mayo Clinic Laboratories -- Rochester Superior Drive
3050 Superior Drive NW
Rochester, MN 55901
Last Updated: November 19, 2021
