Chromosome Analysis, Tissue

For Specimen Integrity during Extreme Weather see the “Lockbox Usage in Extreme Weather” document at the top of this page.

Test Code

CPT Codes
88233, 88262

Physician Attestation of Informed Consent
This germline genetic test requires physician attestation that patient consent has been received if ordering medical facility is located in AK, DE, FL, GA, IA, MA, MN, NV, NJ, NY, OR, SD or VT or test is performed in MA.

*** Test may be replaced by %39650 Cytogenetics Communication and %39667 Chromosome Analysis, Tissue, No Growth ***

Preferred Specimen
5 x 5 tissue collected in a sterile container in Hanks', Ringer's solution or culture medium with antibiotics.

Minimum Volume
2 x 3 mm

Other Acceptable Specimens
Tissue collected in sterile saline

See Genetics Specimen Collection Section for detailed specimen instructions.
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not Reject.

Transport Temperature
Room Temperature

Specimen Stability
Room Temperature = Preferred
Refrigerated = Acceptable
Frozen = Unacceptable

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Karyotype • Microscopy • Tissue Culture

Setup Schedule

Report Available
15 days

Reference Range
See Laboratory Report

Clinical Significance
Chromosome analysis of products of conception (POC) can detect fetal chromosome abnormalities, which are associated with approximately one-half of all first trimester spontaneous abortions. Chromosome testing on fibroblasts obtained from a tissue biopsy is performed to investigate tissue specific mosaicism not present in blood lymphocytes. Fresh cells from tissue biopsies obtained postmortem may still be suitable for chromosome analysis when the patient's blood is not available or viable. If chromosome analysis is unsuccessful, please contact the laboratory genetic counselor at 1-866-GENEINFO (1-866-436-3463) to discuss the option of adding chromosomal microarray (CMA) testing.

Performing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano, CA 92690-6130

Last Updated: November 29, 2021

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.