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Lynch Syndrome Tumor Panel, IHC with Interpretation [91332]
MessageFor Specimen Integrity during Extreme Weather see the “Lockbox Usage in Extreme Weather” document at the top of this page.
Test Code
LYNCHP
Alias/See Also
91332
CPT Codes
88341 (x3), 88342
Includes
MLH1, MSH2, MSH6, PMS2
Preferred Specimen
Formalin-fixed, paraffin-embedded tissue block submitted IHC Specimen Transport Kit
Other Acceptable Specimens
Minimum: 10 unstained, positively charged slildes
Instructions
Please include a surgical pathology report.
Transport Temperature
Room temperature
Specimen Stability
Room temperature: Indefinitely
Refrigerated: Indefinitely
Frozen: Unacceptable
Refrigerated: Indefinitely
Frozen: Unacceptable
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received frozen
Methodology
Immunohistochemistry (IHC)
Setup Schedule
Set up: Mon-Fri; Report available: 3 days
Reference Range
See Laboratory Report
Clinical Significance
Genetic defects in these four mismatch repair proteins underlie most cases of Lynch syndrome or hereditary non-polyposis colorectal carcinoma (HNPCC). This IHC panel looks for loss of expression of one or more of these proteins in cases of suspected HNPCC in tumor tissues from colorectal carcinomas, endometrial carcinomas, sebaceous adenoma/carcinoma or other adnexal tumors. If IHC results are abnormal, guidance is provided in the report on the recommended next step in the workup.
Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153
Last Updated: November 30, 2021