Lynch Syndrome Tumor Panel, IHC with Interpretation

Test Code
91332

CPT Codes
88341 (x3), 88342

Includes
MLH1, MSH2, MSH6, PMS2

Preferred Specimen
Formalin-fixed, paraffin-embedded tissue block submitted IHC Specimen Transport Kit

Other Acceptable Specimens
Minimum: 10 unstained, positively charged slildes

Instructions
Please include a surgical pathology report.

Transport Temperature
Room temperature

Specimen Stability
Room temperature: Indefinitely
Refrigerated: Indefinitely
Frozen: Unacceptable

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received frozen

Methodology
Immunohistochemistry (IHC)

Setup Schedule
Set up: Mon-Fri; Report available: 3 days

Reference Range
See Laboratory Report

Clinical Significance
Genetic defects in these four mismatch repair proteins underlie most cases of Lynch syndrome or hereditary non-polyposis colorectal carcinoma (HNPCC). This IHC panel looks for loss of expression of one or more of these proteins in cases of suspected HNPCC in tumor tissues from colorectal carcinomas, endometrial carcinomas, sebaceous adenoma/carcinoma or other adnexal tumors. If IHC results are abnormal, guidance is provided in the report on the recommended next step in the workup.

Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.