QNatal® Advanced [92777]

Test Code
QNATAL

Alias/See Also
92777

CPT Codes
81420

Includes
Trisome 21, 18 and 13, as well as fetal sex. Also, when a clear result is seen, fetal sex aneuploidies and select microdeletions (22q, 15q, 11q, 8q, 5p, 4p, 1p36) will be reported as additional findings.

Preferred Specimen
10 mL whole blood collected in each two separate Streck cell-free (black/tan tiger-top) glass tubes

Minimum Volume
8 mL (x2)

Instructions
Do not draw before 10 weeks gestation. Use Streck tubes only.
Volume: 20 mL (16 mL minimum) whole blood collected in two Streck cell-free (black/tan tiger-top) glass tubes (10 mL in each tube).

Transport Temperature
Room temperature

Specimen Stability
Room temperature: 7 days
Refrigerate: Unacceptable
Frozen: Unacceptable

Methodology
Next Generation Sequencing

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule
Set up: Daily; Report available: 6-8 days

Reference Range
See Laboratory Report

Clinical Significance
The NIPS screens for fetal chromosomal abnormalities: trisomy 21, 18 and 13, as well as fetal sex. In addition, when a clear result is seen, will also report fetal sex aneuploidies and select microdeletions, including 22q (DiGeorge syndrome), 15q (Prader-Willi/Angelman syndromes), 11q (Jacobsen syndrome), 8q (Langer-Giedion syndrome), 5p (Cri-du-chat syndrome), 4p (Wolf-Hirschhorn syndrome), and 1p36 deletion syndrome as an additional finding.

Performing Laboratory
Quest Diagnostics Nichols Institute San Juan Capistrano
33608 Ortega Highway
San Juan Capistrano, CA 92675



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.