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Paraneoplastic Antibody Evaluation with Reflex to Titer and Line Blot, Basic [93876]
MessageFor Specimen Integrity during Extreme Weather see the “Lockbox Usage in Extreme Weather” document at the top of this page.
Test Code
PARNEO
Alias/See Also
93876
CPT Codes
86255(x10), 86041, 86596(x2) If AChR Binding Antibody is positive (≥0.50) or Equivocal (0.31-0.49), then Paraneoplastic Antibody, LB, Basic and AChR Modulating Antibody will both be performed at additional charges (CPT code(s) 86043).
Includes
If Paraneoplastic Antibody Screen, IFA, Basic is positive for ANNA3, then ANNA-3 Ab, IFA Titer will be performed at an additional charge (CPT code(s) 86256).
If Paraneoplastic Antibody Screen, IFA, Basic is positive for PCA-2, then PCA-2 Ab, IFA Titer will be performed at an additional charge (CPT code(s) 86256).
If Paraneoplastic Antibody Screen, IFA, Basic suggests NMO-5-IgG, then specific CBA-IFA assay will be performed at an additional charge (CPT code(s) 86255).
If Paraneoplastic Antibody Screen, IFA, Basic suggests AMPA-R, GABA-B-R, or NMDA-R, then specific CBA-IFA assay will be performed at an additional charge (CPT code(s) 86255 x4).
If Paraneoplastic Antibody Screen, IFA, Basic is positive or indeterminate, then Paraneoplastic Antibody, LB, Basic will be performed at an additional charge (CPT code(s) 84182 x5, 86341).
If Anti-Striated Muscle Antibody Screen is positive, then Anti-Striated Muscle Antibody Titer will be performed at an additional charge (CPT code(s) 86256).
If AChR Binding Antibody is positive (≥0.50) or Equivocal (0.31-0.49), then Paraneoplastic Antibody, LB, Basic and AChR Modulating Antibody will both be performed at additional charges (CPT code(s) 83519).
If Paraneoplastic Antibody Screen, IFA, Basic is positive for PCA-2, then PCA-2 Ab, IFA Titer will be performed at an additional charge (CPT code(s) 86256).
If Paraneoplastic Antibody Screen, IFA, Basic suggests NMO-5-IgG, then specific CBA-IFA assay will be performed at an additional charge (CPT code(s) 86255).
If Paraneoplastic Antibody Screen, IFA, Basic suggests AMPA-R, GABA-B-R, or NMDA-R, then specific CBA-IFA assay will be performed at an additional charge (CPT code(s) 86255 x4).
If Paraneoplastic Antibody Screen, IFA, Basic is positive or indeterminate, then Paraneoplastic Antibody, LB, Basic will be performed at an additional charge (CPT code(s) 84182 x5, 86341).
If Anti-Striated Muscle Antibody Screen is positive, then Anti-Striated Muscle Antibody Titer will be performed at an additional charge (CPT code(s) 86256).
If AChR Binding Antibody is positive (≥0.50) or Equivocal (0.31-0.49), then Paraneoplastic Antibody, LB, Basic and AChR Modulating Antibody will both be performed at additional charges (CPT code(s) 83519).
Preferred Specimen
6 mL frozen serum
Minimum Volume
3 mL
Transport Container
Transport tube
Transport Temperature
Frozen
Specimen Stability
Room temperature: 48 hours
Refrigerated: 48 hours
Frozen 21 days
Refrigerated: 48 hours
Frozen 21 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Grossly lipemic • Grossly icteric
Methodology
See individual tests
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Varies; Report available: 4-13 days
Reference Range
See Laboratory Report
Clinical Significance
Detection of antineuronal autoantibodies aids the diagnosis of paraneoplastic syndromes and autoimmune encephalopathies and related conditions. Identification of specific antineuronal autoantibodies may direct evaluation for underlying often occult malignancy. Characterization of autoantibody specificity may allow syndromic classification and assist in diagnosis and management. Antineuronal antibodies are detected and characterized based on indirect immunofluorescence staining pattern on multiple neuronal, non-neuronal tissues, and transformed substrate cells, and radioimmunoassays, and western blot analysis.
Performing Laboratory
| Quest Diagnostics Nichols Institute-San Juan Capistrano, CA |
| 33608 Ortega Highway |
| San Juan Capistrano, CA 92675-2042 |
Last Updated: January 1, 2024
