Prolactin, Total and Monomeric [16122]

Message

For Specimen Integrity during Extreme Weather see the “Lockbox Usage in Extreme Weather” document at the top of this page.

Test Code

TMPROL

Alias/See Also

16122

CPT Codes
84146 (x2)

Includes

Prolactin, Total
Prolactin, Monomeric

Preferred Specimen

1 mL serum

Minimum Volume

0.4 mL

Other Acceptable Specimens

Transport Container

Plastic screw-cap vial

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 7 days
Refrigerated: 7 days
Frozen: 6 months

Methodology
Immunoassay (IA) • PEG Precipitation

Setup Schedule

Set up: Wed; Report available: 3 days

Reference Range

Prolactin, Total
Females (>18 years)

Non-pregnant	3.0-30.0 ng/mL
Pregnant	10.0-209.0 ng/mL
Post-menopausal	2.0-20.0 ng/mL

Males (>18 years)

2.0-18.0 ng/mL

Stages of Puberty (Tanner Stages)

	Female Observed	Male Observed
Stage I	3.6-12.0 ng/mL	≤10.0 ng/mL
Stage II-III	2.6-18.0 ng/mL	≤6.1 ng/mL
Stage IV-V	3.2-20.0 ng/mL	2.8-11.0 ng/mL

Prolactin, Monomeric
Adult Reference Ranges for Prolactin, Monomeric

Females	3.2-25.2 ng/mL
Males	3.4-14.8 ng/mL

Clinical Significance

For some patients the level of Prolactin measured by immunoassay may be inaccurate with respect to the level of monomeric, biologically active Prolactin. The Macroprolactin by PEG Precipitation test can help to identify if a patient sample has elevated Prolactin due to mostly inactive protein-bound Prolactin (Macroprolactin).

Performing Laboratory

Quest Diagnostics Nichols Institute-San Juan Capistrano, CA

33608 Ortega Highway

San Juan Capistrano, CA 92675-2042

Last Updated: December 6, 2021

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.