Cryoglobulin (%Cryocrit), Serum

For Specimen Integrity during Extreme Weather see the “Lockbox Usage in Extreme Weather” document at the top of this page.

Due to special collection requirements this specimen can only be collected by our Sandridge Patient Service Center (preferred), MVH Out-Patient Service Center (Berry Center Outpatient Lab) or in a hospital following the specimen processing instructions below.

Test Code

Alias/See Also

CPT Codes

Preferred Specimen
10 mL serum Red top tube with no additives .

Overnight Fasting is suggested. Avoid hemolysis.
1. 2 Red top tubes should be collected and placed in a prewarmed thermos (37º C) containing sand immediately after collection.
2. Samples should be brought back to the lab where they are placed in a 37º C waterbath for 1 hour to allow the tubes to clot.
3. After the 1 hour incubation period the tubes need to be centrifuged in a pre-warmed centrifuge for 10 mins at 5000 rpm.
(If no heated centrifuge is available, allow centrifuge to cycle 1 round to warm it up then proceed to spin tubes down.)
4. Remove serum into 2 pour off tubes and send into Sandridge Reference Lab.
5. Cryoglobulin, if present, will be lost in the clot if processed below 37º C.
6. Ship at room temperature. Do not refrigerate or freeze.

Transport Container
Red top tube

Transport Temperature
Room Temperature

Specimen Stability
Special collection

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Rejected for gross hemolysis, lipemia, received refrigerated or frozen


Setup Schedule
Monday - Friday

Report Available
8 days

Clinical Significance
The Cryocrit is primarily intended for following a patient with previously defined and quantitated Cryoglobulins. The Cryocrit may consist of Cryoglobulins, fibrin or mixtures of Cryoglobulins and fibrin.

Performing Laboratory
Compunet Clinical Laboratories, LLC
2308 Sandridge Drive
Moraine, OH 45439

Last Updated: December 7, 2021

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.