Rickettsia (Typhus Fever) Antibodies (IgG, IgM) with Reflex to Titers [37503]

Message
For Specimen Integrity during Extreme Weather see the “Lockbox Usage in Extreme Weather” document at the top of this page.


Test Code
TYPHUS


Alias/See Also
37503


CPT Codes
86757 (x2)

Includes
If R. typhi IgG is Detected, then R. typhi IgG Titer will be performed at an additional charge (CPT code(s): 86757).
If R. typhi IgM is Detected, then R. typhi IgM Titer will be performed at an additional charge (CPT code(s): 86757).


Preferred Specimen
1 mL serum


Minimum Volume
0.2 mL


Transport Container
Plastic screw-cap vial


Transport Temperature
Room temperature


Specimen Stability
Room temperature: 7 days
Refrigerated: 14 days
Frozen: 30 day


Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Grossly lipemic


Methodology
Immunofluorescent Assay (IFA)

Setup Schedule
Set up: Tues-Sat a.m.; Report available: Next day


Limitations
Even after infection has been treated, positive results may persist. False-positive reactions may occur during pregnancy.


Reference Range
Screen Titer
R. typhi IgG Not detected <1:64
R. typhi IgM Not detected <1:64


Clinical Significance
Antigen specific IgG and IgM titers allow rapid diagnosis of infection by one or more of the typhus fever group of rickettsial agents. This group includes Rickettsia typhi (endemic or murine typhus) R. prowazeki (epidemic typhus), and Brill-Zinsser disease caused by reactivation of latent R. prowazeki.


Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153



Last Updated: December 6, 2021


The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.