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First Trimester Screen, hCG [16145]
MessageFor Specimen Integrity during Extreme Weather see the “Lockbox Usage in Extreme Weather” document at the top of this page.
Test Code
FTHCG
Alias/See Also
16145
CPT Codes
84163, 84702 OR 81508* *The 2017 AMA CPT codebook contains the component CPT codes and the new MAAA codeset. Please direct any questions regarding coding to the payor being billed.
Includes
PAPP-A (Pregnancy-associated Plasma Protein-A), hCG, Maternal Risk calculation which includes NT (Nuchal Translucency)
Preferred Specimen
1.5 mL serum
Minimum Volume
0.8 mL
Instructions
Collect between 10.0 weeks to 13.9 (13 6/7) weeks. Perform between 10.0 to 13.9 (13 6/7) weeks gestational age. A special Maternal Serum Screen requisition designed to obtain patient data and the patient's informed consent must be used when ordering this test, because these results are influenced by certain patient characteristics. All data requested on the requisition form must be complete to permit accurate interpretation of results.
Transport Container
Plastic screw-cap vial
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 14 days
Refrigerated: 14 days
Frozen: 28 days
Refrigerated: 14 days
Frozen: 28 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis
Methodology
Calculation (CALC) • Chemiluminescence (CL) • Immunoassay (IA)
FDA Status
*PAPP-A Component only: This test was performed using a kit that has not been cleared or approved by the FDA. The analytical performance characteristics of this test have been determined by Quest Diagnostics. This test should not be used for diagnosis without confirmation by other medically established means.
Setup Schedule
Set up: Mon-Sat; Report available: 4-6 days
Limitations
First Trimester Screen results consistent with increased risk of trisomy should be confirmed with CVS or amniotic fluid specimen. Maternal serum screening yields a low percentage of false negatives. A wide range of other chromosomal abnormalities are not identified by maternal serum screening.
Reference Range
MSS Down Syndrome Risk: <1:270
MSS Trisomy 18 Risk: <1:100
MSS Trisomy 18 Risk: <1:100
Clinical Significance
To screen for Down Syndrome and Trisomy 18 at 10.0-13.9 weeks gestation.
Performing Laboratory
Quest Diagnostics Nichols Institute-San Juan Capistrano, CA |
33608 Ortega Highway |
San Juan Capistrano, CA 92675-2042 |
Last Updated: November 29, 2021