Porphyrins, Fractionated, Quantitative, Random Urine [36592]

Message

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If you have any questions regarding these results, please contact the Quest Diagnostics Biochemical Genetics Laboratory at 1-800-642-4657 Ext. 4817 or Ext. 4423 and ask to speak with the laboratory director on call. For general questions about Quest Diagnostics genetic testing, please call the Gene Info line at 1-866-GENE-INFO.

Test Code

PORPFR

Alias/See Also

36592

CPT Codes
84120

Includes

Coproporphyrin I, Coproporphyrin III, Heptacarboxyporphyrin, Hexacarboxyporphyrin, Pentacarboxyporphyrin, Uroporphyrin I, Uroporphyrin III, Total Porphyrins

Preferred Specimen

2 mL random urine in 5 grams sodium carbonate (Na2CO3) container - protected from light

Minimum Volume

1.5 mL

Other Acceptable Specimens

Unpreserved random urine submitted in a plastic leak-proof container (light protected) • Unpreserved catheterized or first void clean catch or random clean catch urine (light protected)

Instructions

Random urine collected with 5 grams of sodium carbonate, refrigerated, and protected from light during collection is preferred. Collection with no preservative is acceptable, if properly refrigerated and light protected.

Transport Container

Transport Temperature

Refrigerated (cold packs) - ok to thaw

Specimen Stability

Room temperature: Unacceptable
Refrigerated: 7 days
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Received room temperature • Samples not protected from light • Samples with a pH <4.0

Methodology
High Performance Liquid Chromatography (HPLC)

Setup Schedule

Set up: Sun, Tues-Fri; Report available: 5-7 days

Reference Range

Uroporphyrin I	3.6-21.1 mcg/g creat
Uroporphyrin III	≤5.6 mcg/g creat
Heptacarboxyporphyrin	≤3.4 mcg/g creat
Hexacarboxyporphyrin	≤6.3 mcg/g creat
Pentacarboxyporphyrin	≤4.1 mcg/g creat
Coproporphyrin I	6.5-33.2 mcg/g creat
Coproporphyrin III	4.8-88.6 mcg/g creat
Total Porphyrins	27.0-153.6 mcg/g creat

Clinical Significance

Porphyria is a group of distinct disorders, characterized by the abnormal accumulation of porphyrins or porphyrin precursors. Porphyrin fractionation of urine is useful in diagnosing porphyrin cutanea tarda, hereditary coproporphyria, and variegate porphyria.

Performing Laboratory

Quest Diagnostics Nichols Institute-San Juan Capistrano, CA

33608 Ortega Highway

San Juan Capistrano, CA 92675-2042

Last Updated: December 6, 2021

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.