A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #

Porphyrins, Fractionated, Plasma [5519]

Message
For Specimen Integrity during Extreme Weather see the “Lockbox Usage in Extreme Weather” document at the top of this page.


Test Code
PORPFP


Alias/See Also
5519


CPT Codes
82542

Includes
Uroporphyrin, Heptacarboxyporphyrin, Hexacarboxyporphyrin, Pentacarboxyporphyrin, Coproporphyrin, Protoporphyrin, Total Porphyrins


Preferred Specimen
2 mL plasma collected in a sodium heparin (green-top) tube - light protected


Minimum Volume
0.6 mL


Other Acceptable Specimens
Plasma collected in an EDTA (lavender-top) tube - light protected • Serum collected in a red-top tube (no gel) - light protected


Instructions
Collect blood sample with foil-wrapped green-top tube. Separate plasma by centrifugation. Avoid hemolysis. Remove plasma to a light-protected tube. Freeze immediately after separation.


Transport Container
Plastic screw-cap vial, protected from light


Transport Temperature
Frozen


Specimen Stability
Room temperature: 8 hours
Refrigerated: 8 hours
Frozen: 90 days


Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis • Received room temperature • Received refrigerated • Not protected from light • Serum Separator Tube (SST®)


Methodology
High Performance Liquid Chromatography (HPLC)

Setup Schedule
Set up: Sun, Wed; Report available: 5-10 days


Reference Range
Uroporphyrin≤0.2 mcg/L
Heptacarboxyporphyrin≤0.2 mcg/L
Hexacarboxyporphyrin≤0.3 mcg/L
Pentacarboxyporphyrin≤0.4 mcg/L
Coproporphyrin≤0.8 mcg/L
Protoporphyrin0.4-4.8 mcg/L
Total Porphyrins1.0-5.6 mcg/L


Clinical Significance
Porphyria is a group of distinct disorders characterized by the abnormal accumulation of porphyrins or porphyrin precursors. Porphyrin fractionation of plasma is useful in diagnosing certain types of porphyrias and excluding porphyrias in patients with chronic renal failure suspected of having a porphyria.


Performing Laboratory
Quest Diagnostics Nichols Institute-San Juan Capistrano, CA
33608 Ortega Highway
San Juan Capistrano, CA 92675-2042



Last Updated: December 6, 2021


The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.