Yo Antibody Screen with Reflex to Titer and Western Blot, CSF [90117]

Message

For Specimen Integrity during Extreme Weather see the “Lockbox Usage in Extreme Weather” document at the top of this page.

Test Code

YOABCF

Alias/See Also

90117

CPT Codes
86255

Includes

If Yo Antibody Screen, IFA, CSF is positive, Yo Antibody, Western Blot, CSF will be performed at an additional charge (CPT code(s): 84181).
If Yo Antibody, Western Blot, CSF is positive, Yo Antibody, Titer, CSF will be performed at an additional charge (CPT code(s): 86256).

Preferred Specimen

0.8 mL CSF

Patient Preparation
Overnight fasting is preferred

Minimum Volume

0.5 mL

Transport Container

Sterile screw-cap vial

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 8 hours
Refrigerated: 7 days
Frozen: 6 months

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Received room temperature

Methodology
Immunofluorescence Assay (IFA)

FDA Status
This test was developed and its performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. Performance characteristics refer to the analytical performance of the test.

Setup Schedule

Set up: Mon, Wed, Fri a.m; Report available: 4 days

Reference Range

Yo Ab Screen, IFA, CSF

Negative

Yo Ab, WB, CSF	Negative
Yo Ab, Titer, CSF	No Yo Antibodies detected in undiluted CSF sample

Clinical Significance

Purkinje Cell (Yo) antibody is found in approximately half of the patients with paraneoplastic cerebellar degeneration and is associated with ovarian, uterine, and small cell lung carcinomas and Hodgkin’s lymphoma.

Performing Laboratory

Quest Diagnostics Nichols Institute-San Juan Capistrano, CA

33608 Ortega Highway

San Juan Capistrano, CA 92675-2042

Last Updated: December 7, 2021

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.